Publications
Discovery of new benzothiazole-1,2,3-triazole hybrid-based hydrazone/thiosemicarbazone derivatives as potent EGFR inhibitors with cytotoxicity against cancer
Albujuq N.R.; Aljuhani A.; Alraqa S.Y.; Alsehli M.; Aouad M.R.; Bardaweel S.K.; Darwish K.M.; Nafie M.S.; Rezki N.
RSC Advances
Jan 2025
Topical loratadine-loaded invasomal gel repurposed for vulvovaginal candidiasis; in vitro, in silico, ex vivo, and in vivo studies
Abdellatif M.M.; Abdelmonem R.; Darwish K.M.; I. A. Hamed M.; Ibrahim Al-Samadi I.E.; Magdy William M.; Omar Rashwan K.
International journal of pharmaceutics
Jan 2025
Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy
Abdelwaly A.M.; Atta A.M.; Darwish K.M.; Elgawish M.S.; Helal M.A.; Moustafa S.M.; Nafie M.S.; Rihan N.
RSC Medicinal Chemistry
Jan 2025
Development of 1,2,3-triazole hybrids as multi-faced anticancer agents co-targeting EGFR/mTOR pathway and tubulin depolymerization
Darwish K.M.; El-Sayed M.A.-A.; Kishk S.M.; Salama I.; Shaheen M.A.
Bioorganic chemistry
Jan 2025
Discovery of novel tris-1,2,3-triazole-based hybrids as VEGFR2 inhibitors with potent anti-proliferative and cytotoxicity through apoptosis induction
Aljuhani A.; Alraqa S.Y.; Alsehli M.; Aouad M.R.; Bardaweel S.; Darwish K.M.; Nafie M.S.; Rezki N.; Sheikh Ali A.A.
Bioorganic chemistry
Jan 2025
Revealing Pharmacokinetic Interactions of Tramadol, Tapentadol, and Venlafaxine: A Cutting-Edge Liquid Chromatography-Tandem Mass Spectrometry Analytical Approach in Rat Plasma
Darwish K.M.; Elgawish M.S.; Heneedak H.M.; Mostafa S.M.
ACS Pharmacology & Translational Science
Jan 2025
Nanocomposite alginate hydrogel loaded with propranolol hydrochloride kolliphor® based cerosomes as a repurposed platform for Methicillin-Resistant Staphylococcus aureus-(MRSA)-induced skin infection; in-vitro, ex-vivo, in-silico, and in-vivo evaluation
Abdellatif M.M.; Darwish K.M.; El-Nabarawi M.A.; Eltabeeb M.A.; Hamed M.I.A.; Hamed R.R.; Hassan M.; Teaima M.H.
Drug Delivery and Translational Research
Jan 2025
Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach
Abdelfattah M.M.; Barakat A.; Darwish K.M.; Diab M.K.; El-Faham A.; Fahmy S.A.; Hassen B.M.; Nafie M.S.; Shawish I.
RSC Advances
Jan 2025
Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection
A Hamed M.I.; Abdellatif M.M.; Darwish K.M.; El-Nabarawi M.A.; Eltabeeb M.A.; Hamdan A.M.E.; Hamed R.R.; Hassan M.; Teaima M.H.
Nanomedicine
Jan 2024
Nuciferol C, a new sesquineolignan dimer from Cocos nucifera L.: bioactivity and theoretical investigation
Alnajjar R.; Darwish K.M.; Elsbaey M.; Igarashi Y.; Miyamoto T.
RSC Advances
Jan 2024
Atropisomerism in Drug Discovery and Development
Darwish K.M.; Hamed M.I.A.; Helal M.A.; Husseiny E.M.; Yassen A.S.A.
Wiley Online Library
Jan 2024
Novel curcumin-based analogues as potential VEGFR2 inhibitors with promising metallic loading nanoparticles: synthesis, biological evaluation, and molecular modelling investigation
Abdel-Wahab S.M.; Abdelhameed R.F.A.; Attia K.M.; Darwish K.M.; El-Batal A.I.; El-Sayyad G.S.; Elrayess R.; Elshihawy H.A.; Nafie M.S.; Yassen A.S.A.
RSC Medicinal Chemistry
Jan 2024
Green innovation in analytical chemistry: A sustainable densitometric HPTLC approach for the distinctive separation and quantification of structurally related abused drugs - tramadol, tapentadol, and venlafaxine - in seized pharmaceutical dosage forms
Abdelshakour M.A.; Darwish K.M.; Elgawish M.S.; Heneedak H.M.; Mostafa S.M.
Journal of Pharmaceutical and Biomedical Analysis
Jan 2024
Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E—In Vitro and In Silico Investigations
Darwish K.M.; Elhady S.S.; Elkady W.M.; Elkhawas Y.A.; Fathallah N.; Zahran S.A.
Pharmaceuticals
Jan 2024
In vivo determination of analgesic and anti-inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds
Abd EL-Sameaa A.M.; Ahmed S.A.; Badawy A.M.; Darwish K.M.; El-Ayouty M.M.; Elhady S.S.; Eltahawy N.A.; Shokr M.M.
RSC Advances
Jan 2024
Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma: isolation, structure elucidation, molecular modelling studies, and in vitro activities
Ahmed S.A.; Badawy A.M.; Darwish K.M.; Donia M.S.M.; El-Ayouty M.M.; Hamdy N.G.; Mohamed O.G.; Tripathi A.
Organic & Biomolecular Chemistry
Jan 2024
Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation
Albelwi F.F.; Albujuq N.R.; Aljuhani A.; Darwish K.M.; Hourani W.; Nafie M.S.; Reda Aouad M.; Rezki N.; Samir Ayed A.
Bioorganic Chemistry
Jan 2024
Design and synthesis of chromene-1,2,3-triazole benzene sulfonamide hybrids as potent carbonic anhydrase-IX inhibitors against prostate cancer
Albelwi F.F.; Albujuq N.R.; Aljuhani A.; Aouad M.R.; Darwish K.M.; Hourani W.; Nafie M.S.; Rezki N.; Tawfik M.M.
RSC Medicinal Chemistry
Jan 2024
Unveiling Pharmacokinetics and Drug Interaction of Linagliptin and Pioglitazone HCl in Rat Plasma Using LC-MS/MS
Aref H.; Darwish K.M.; Elgawish M.S.; Hammad S.
Chemical Research in Toxicology
Jan 2024
Development of a novel papain gel formulation: Exploring different concentrations for smear-layer deproteinization and enhanced dentin bonding
Abdou A.; Darwish K.M.; Kusumasari C.; Megantoro A.; Meidyawati R.; Meiskya A.; Tiara R.
Heliyon
Jan 2024
Synthesis and characterization of mixed-ligand Co(II) complexes with gabapentin or pregabalin and diimine coligands: DNA interaction, antibacterial, antifungal and molecular docking studies
Abdelrahman R.B.; Darwish K.M.; Mahmoud M.A.
Journal of Molecular Structure
Jan 2024
Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders
Abourobe N.M.; Darwish K.M.; Elrayess R.; Fattah S.A.; Ghareb N.; Hazem R.M.; Mehanna E.T.; Nafie M.S.
RSC Medicinal Chemistry
Jan 2024
Developing small molecule inhibitors against the opioid receptor
Ahmad Abdelwaly; Amar Chittiboyina; Khaled M. Darwish; Mohamed A. Helal
ACS National Meeting and Exposition; Harnessing the Power of Data
Aug 2023
Unraveling Extremely Damaging IRAK4 Variants and Their Potential Implications for IRAK4 Inhibitor Efficacy
Aldehri M.; Alshehri M.A.; Asiri A.; Behairy M.Y.; Darwish K.M.; Eid R.A.; El-Shaer N.H.; Eldeen M.A.; Elhady S.S.; Mohammed H.M.; Otifi H.M.; Zaki M.S.A.
Journal of Personalized Medicine
Jan 2023
Deciphering Molecular Aspects of Potential alpha-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling
Abdelhameed R.F.A.; Alharbi M.; Alshobaki N.M.; Darwish K.M.; Elfaky M.A.; Elhady S.S.; Koshak A.E.
Metabolites
Jan 2023
The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens
Abu Lila A.S.; Ali M.A.M.; Alotaibi H.; Alotaibi H.F.; Alshawwa S.Z.; Darwish K.M.; Hegazy W.A.H.; Khafagy E.-S.
Biomedicines
Jan 2023
Molecular and Biological Investigation of Isolated Marine Fungal Metabolites as Anticancer Agents: A Multi-Target Approach
Abdelhameed R.F.A.; Aldurdunji M.M.; Almalki A.J.; Alshehri S.O.; Bogari H.A.; Darwish K.M.; Elhady S.S.; Khedr A.I.M.; Lashkar M.O.; Malatani R.T.; Mohamed R.A.; Refaey M.S.; Yamada K.
Metabolites
Jan 2023
Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy
Abdelhameed R.F.A.; Ahmed H.E.M.; Al-Salmi F.A.; Al-Shraim M.; Darwish K.M.; Eid R.A.; Eldeen M.A.; Fayad E.; Hassan H.M.; Jafri I.; Negm A.; Noreldin A.E.; Sajer B.H.; Soltan M.A.
Biology
Jan 2023
Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation
Albash R.; Badawi N.M.; Darwish K.M.; Elbesh R.M.; Elhady S.S.; Hamed M.I.A.; Lashkar M.O.; Mohammed S.S.; Mosallam S.; Ragaie M.H.
Pharmaceuticals
Jan 2023
Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection
Abd-Elghany K.; Ahmad T.A.; Aldurdunji M.M.; Ateya M.A.-M.; Bogari H.A.; Darwish K.M.; Elbatreek M.H.; Elhady S.S.; Elnahas H.M.; Gouda A.M.; Lashkar M.O.; Said A.M.; Sileem A.E.; Soltan M.A.
Frontiers in molecular biosciences
Jan 2023
Insights into the selectivity of small molecule inhibitors against the kappa opioid receptor: A comparative computational investigation
Ahmad Abdelwaly; Amar Chittiboyina; Khaled M. Darwish; Mohamed A. Helal
ACS National Meeting and Exposition; Sustainability in a changing world
Aug 2022
Discovery of tetrahydro-?-carboline- and indole-based derivatives as promising phosphodiesterase-4 inhibitors: Synthesis, biological evaluation, and molecular modeling studies
Abdelwaly A.; Atta A.M.; Darwish K.M.; Helal M.A.
Journal of Molecular Structure
Jan 2022
Repurposing levocetirizine hydrochloride loaded into cationic ceramide/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies
Alahdal A.M.; Albash R.; Darwish K.M.; El-Dahmy R.M.; Fahmy A.M.; Hamed M.I.A.; Kassem A.B.
Drug Delivery
Jan 2022
Mining of Marburg Virus Proteome for Designing an Epitope-Based Vaccine
Abdulsahib W.K.; Albogami S.; Amer M.; Bagalagel A.A.; Darwish K.M.; Diri R.M.; Eid R.A.; Eldeen M.A.; Elhady S.S.; Fayad E.; Refaat A.M.; Sharaf S.M.A.; Soltan M.A.
Frontiers in Immunology
Jan 2022
HBD-2 variants and SARS-CoV-2: New insights into inter-individual susceptibility
Abdel-Daim M.M.; Abdulhakim J.A.; Al-Qahtani S.M.; Albogami S.; Alnoman M.M.; Alsharif G.; Behairy M.Y.; Darwish K.M.; Eid R.A.; Eldeen M.A.; Elhady S.S.; Fayad E.; Jafri I.; Otifi H.; Soltan M.A.; Zaki M.S.A.
Frontiers in Immunology
Jan 2022
Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies
Al-Karmalawy A.A.; Ashour A.; Darwish K.M.; Elhady S.S.; Zaki A.A.
Journal of Traditional and Complementary Medicine
Jan 2022
Hiring of the Anti-Quorum Sensing Activities of Hypoglycemic Agent Linagliptin to Alleviate the Pseudomonas aeruginosa Pathogenesis
Abbas H.A.; Alharbi M.; Ali M.A.M.; Darwish K.M.; Hegazy W.A.H.; Ibrahim T.S.; Khafagy E.-S.; Khayat M.T.; Khayyat A.N.
Microorganisms
Jan 2022
In Silico and in Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
Al-Karmalawy A.A.; Boseila A.A.; Chrouda A.; Darwish K.M.; Elhady S.S.; Elmaaty A.A.; Mustafa M.; Shaik A.B.; Tantawy M.A.
ACS Omega
Jan 2022
Repurposing alpha-Adrenoreceptor Blockers as Promising Anti-Virulence Agents in Gram-Negative Bacteria
Almalki A.J.; Darwish K.M.; Elhady S.S.; Hegazy W.A.H.; Ibrahim T.S.
Antibiotics
Jan 2022
Computational Analysis of Deleterious SNPs in NRAS to Assess Their Potential Correlation With Carcinogenesis
Adam M.S.; Alaa Eldeen M.; Albogami S.; Althobaiti F.; Behairy M.Y.; Darwish K.M.; Elfaky M.A.; Ezz E.M.; Fayad E.; Gouda A.M.; Refaat A.M.; Sileem A.E.; Soltan M.A.
Frontiers in Genetics
Jan 2022
Bio-Guided Isolation of SARS-CoV-2 Main Protease Inhibitors from Medicinal Plants: In Vitro Assay and Molecular Dynamics
Abdallah H.M.; Abdel-Naim A.B.; Algandaby M.M.; Alqarni A.A.; Darwish K.M.; El-Halawany A.M.; Elfaky M.A.; Elhady S.S.; Fadil S.A.; Ibrahim S.R.M.; Koshak A.E.; Mohamed G.A.
Plants
Jan 2022
In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins
Al?Karmalawy A.A.; Darwish K.M.; Elhady S.S.; Elmaaty A.A.; Hamed M.I.A.; Khattab M.; Salah M.; Saleh M.M.
Journal of biomolecular structure & dynamics
Jan 2022
Phenolics from Chrozophora oblongifolia Aerial Parts as Inhibitors of ?-Glucosidases and Advanced Glycation End Products: In-Vitro Assessment, Molecular Docking and Dynamics Studies
Abdallah H.M.; Abdel-Naim A.B.; Algandaby M.M.; Darwish K.M.; El-Halawany A.M.; Elhady S.S.; Ibrahim S.R.M.; Kashegari A.T.; Koshak A.E.; Mohamed G.A.; Proksch P.; Shalabi A.A.
Biology
Jan 2022
In silico Designing of an Epitope-Based Vaccine Against Common E. coli Pathotypes
Abdelkader M.S.; Alaa Eldeen M.; Albogami S.; Behairy M.Y.; Darwish K.M.; Eid R.A.; Elhady S.S.; Fayad E.; Lotfy A.M.; Soltan M.A.
Frontiers in Medicine
Jan 2022
Anti-Quorum Sensing Activities of Gliptins against Pseudomonas aeruginosa and Staphylococcus aureus
Abbas H.A.; Alharbi M.; Darwish K.M.; Elhady S.S.; Hegazy W.A.H.; Ibrahim T.S.; Khafagy E.-S.; Khayat M.T.; Khayyat A.N.; Safo M.K.
Biomedicines
Jan 2022
Computational and Biological Evaluation of beta-Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents
Almalki A.J.; Darwish K.M.; Elhady S.S.; Hegazy W.A.H.; Ibrahim T.S.
Pharmaceuticals
Jan 2022
Quinoline-hydrazone hybrids as dual mutant EGFR inhibitors with promising metallic nanoparticle loading: rationalized design, synthesis, biological investigation and computational studies
Darwish K.M.; El-Sayyed G.S.; Elrayess R.; Nafie M.S.; Said M.M.; Yassen A.S.A.
New Journal of Chemistry
Jan 2022
Antioxidant and anti-inflammatory activity of cynanchum acutum l. Isolated flavonoids using experimentally induced type 2 diabetes mellitus: Biological and in silico investigation for nf-?b pathway/mir-146a expression modulation
Abdelhameed R.F.A.; Ahmed S.A.; Darwish K.M.; Elfaky M.A.; Elhady S.S.; Habib E.S.; Ibrahim A.K.; Khodeer D.M.; Mahamed M.I.; Mehanna E.T.
Antioxidants
Jan 2021
Deciphering the molecular basis of the kappa opioid receptor selectivity: A Molecular Dynamics study
Abdelwaly A.; Chittiboyina A.; Darwish K.M.; Eissa A.A.H.M.; Helal M.A.; Saleh A.H.
Journal of Molecular Graphics and Modelling
Jan 2021
Investigating the structure-activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors
Abdel-Aziz T.M.; Al-Karmalawy A.A.; Darwish K.M.; El-Demerdash A.; Elhady S.S.; Hassan A.H.E.
RSC Advances
Jan 2021
In silico designing of a multitope vaccine against rhizopus microsporus with potential activity against other mucormycosis causing fungi
Abdelraheem K.M.; Abu Ali O.A.; Darwish K.M.; El-Damasy D.A.; El-Gayyed H.A.; Elbassiouny N.; Eldeen M.A.; Elhady S.S.; Fayad E.; Ghany K.A.E.; Gouda A.M.; Kamel H.L.; Sheha M.F.; Sileem A.E.; Soltan M.A.
Cells
Jan 2021
Molecular docking and dynamics simulation study of hyrtios erectus isolated scalarane sesterterpenes as potential sars-cov-2 dual target inhibitors
Abdelhameed R.F.A.; Ahmed S.A.; Alahdal A.M.; Almalki A.J.; Bogari H.A.; Darwish K.M.; Elhady S.S.; Khedr A.I.M.; Malatani R.T.; Mohammad K.A.
Biology
Jan 2021
Beta-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: Rational based design,: In silico, in vitro, and SAR studies for lead optimization
Abo Shama N.M.; Abulkhair H.S.; Al-Karmalawy A.A.; Chrouda A.; Darwish K.M.; Elhady S.S.; Elmaaty A.A.; Hamed M.I.A.; Khodir A.E.; Mostafa A.; Soltane R.
RSC Advances
Jan 2021
Vegfr-mediated cytotoxic activity of pulicaria undulata isolated metabolites: A biological evaluation and in silico study
Abdelhameed R.F.A.; Ahmed S.A.; Darwish K.M.; Elhady S.S.; Habib E.S.; Hassanean H.A.; Hazem R.M.; Ibrahim A.K.; Mohammad K.A.; Zekry S.H.
Life
Jan 2021
Repurposing of sitagliptin-melittin optimized nanoformula against sars-cov-2: Antiviral screening and molecular docking studies
Ahmed O.A.A.; Al-Rabia M.W.; Aldarmahi A.A.; Alhakamy N.A.; Aloafi A.L.; Asfour H.Z.; Darwish K.M.; Eljaaly K.; Fahmy U.A.; Ibrahim T.S.; Mostafa A.
Pharmaceutics
Jan 2021
Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: In silico studies, statistical optimization, ex vivo, and in vivo studies
Albash R.; Darwish K.M.; El-Dahmy R.M.; Fahmy A.M.; Hamed M.I.A.
Drug Delivery
Jan 2021
Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor
Al-Karmalawy A.A.; Dahab M.A.; Darwish K.M.; Eissa I.H.; Elhady S.S.; Elkaeed E.B.; Metwaly A.M.
Frontiers in Chemistry
Jan 2021
Design, synthesis, anticancer activity, and solid lipid nanoparticle formulation of indole-and benzimidazole-based compounds as pro-apoptotic agents targeting bcl-2 protein
Darwish K.M.; Kishk S.M.; Mostafa S.M.; Nagy M.I.; Nasr A.M.; Qushawy M.; Salama I.; Swidan S.A.; Tantawy M.A.
Pharmaceuticals
Jan 2021
Simultaneous Determination of Losartan and Rosuvastatin in Rat Plasma Using Liquid Chromatography–Tandem Mass Spectrometric Technique for Application into Pharmacokinetic and Drug–Drug Interaction Studies
Darwish K.M.; Elgawish M.S.; Kishk S.M.; Mostafa S.M.; Wadie M.A.
Chromatographia
Jan 2020
Novel spectrofluorimetric quantification of linagliptin in biological fluids exploiting its interaction with 4-chloro-7-nitrobenzofurazan
Aref H.A.; Darwish K.M.; Elgawish M.S.; Hammad S.F.
Luminescence
Jan 2020
The anticancer activity for the bumetanide-based analogs via targeting the tumor-associated membrane-bound human carbonic anhydrase-IX enzyme
Darwish K.M.; El-Sabbagh O.I.; Ibrahim T.S.; Khayyat A.N.; Malebari A.M.; Mostafa S.M.; Salama I.; Salem I.M.
Pharmaceuticals
Jan 2020
Novel spectrofluorimetric quantification of alogliptin benzoate in biofluids exploiting its interaction with 4-chloro-7-nitrobenzofurazan
Aref H.A.; Darwish K.M.; Elgawish M.S.; Hammad S.F.
Luminescence
Jan 2020
Acalypha wilkesiana flowers: Phenolic profiling, cytotoxic activity of their biosynthesized silver nanoparticles and molecular docking study for its constituents as Topoisomerase-I inhibitors
Darwish K.M.; El Raey M.A.; El-Hagrassi A.M.; Emam M.; Osman A.F.
Biocatalysis and Agricultural Biotechnology
Jan 2019
Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-?/FFAR1 agonists
Darwish K.M.; Gomaa M.S.; Helal M.A.; Khafagy E.-S.; Mostafa S.; Salama I.
Bioorganic & Medicinal Chemistry Letters
Jan 2018
Rational design and stereoselective synthesis of novel naturally derived PDE4 inhibitors
E. Habib; Khaled M. Darwish; Mohamed A. Helal
251th ACS National Meeting and Exposition
Mar 2016
Design, synthesis, and biological evaluation of novel thiazolidinediones as PPAR3/FFAR1 dual agonists
Darwish K.M.; Gomaa M.S.; Helal M.A.; Mostafa S.; Salama I.
European Journal of Medicinal Chemistry
Jan 2016
Design and synthesis of antidiabetic agents with agonistic activity on both PPARγ and FFAR
Ismail Salama; Khaled M. Darwish; Mohamed A. Helal; Mohamed Gomaa; Samia Mostafa
248th ACS National Meeting and Exposition, San Francisco, CA, USA
Aug 2014
Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation
Darwish K.M.; Hammad M.A.; Helal M.A.
Bioorganic & Medicinal Chemistry Letters
Jan 2014
Design and development of novel agents with agonistic activity on both PPARγ and FFAR
Khaled M. Darwish; Mohamed A. Helal
2nd International Conference on Applied Life Sciences, Dubai, UAE
Sep 2013
RP-HPLC/pre-column derivatization for analysis of omeprazole, tinidazole, doxycycline and clarithromycin
Darwish K.M.; El-Sadek M.; Mostafa S.; Salama I.
Journal of chromatographic science
Jan 2013
Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin
Darwish K.; El-Sadekb M.; Mostafa S.; Salama I.
journal Chemical and Pharmaceutical Bulletin (Tokyo)
Jan 2012
Extractional spectrophotometric analysis of metronidazole, tinidazole, ornidazole and secnidazole bases through acid-dye complexation using bromothymol blue dye
Darwish K.M.; El-Sadek M.; Mostafa S.; Salama I.
Pakistan Journal of Pharmaceutical Sciences
Jan 2012
Biography
Khaled M. Darwish, is currently an Associate Professor of Medicinal Chemistry, Faculty of Pharmacy, Galala University, Egypt. He has more than ten years of experience within the field of organic synthesis and molecular modeling, participating in several research projects both domestically and internationally. He received his PhD. as junior scientist funded by STDF, Egypt, 4244 for Design and synthesis of novel heterocyclic compounds as potential anti-diabetic agents. In 2016, he collaborated as post-doc to finish an open-project funded by STDF (4711) Design and synthesis of PDE4 inhibitors for treatment of COPD. In 2019, he received a two-year grant as PI from US-STDF Joint Fund (USC18-1086) for Design and synthesis of novel kappa opioid receptor ligands for treatment of addiction as a collaboration between Suez Canal University and Mississippi University USA. He further received grant as PI from US-STDF next round (USC20-45896) for Targeting Kv1.3 voltage-gated potassium channel, to design safe and novel immunomodulators as a collaboration with Temple University USA, Awarded certificate of Best Internationally Funded Project, Vice president of Post-graduate and research affairs, Suez Canal University. Current member of the American Chemical Society (ACS), United States, Membership Badge 201179. Member of the Editorial Board of the Scientific Journal, Faculty of Pharmacy - Suez Canal University; Records of Pharmaceutical and Biomedical Sciences ISSN:2536-9857/2535-2091.
Current research interest involves;
• Rational design and de-novo design, synthesis and testing of new therapeutic agents for the management of cancer, metabolic, and cardiovascular diseases which are the main causes of death all over the world.
• Development of new ant-infective agents covering antibacterial, antiviral and antifungal agents. Targets include P450 enzymes, reverse transcriptase and DNA polymerase.
Qualifications & IDs
Author IDs
Scopus Author ID
59554399000
Researcher ID
M-1052-2019
Research Output
Explore all research publications from Galala University scholars.
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