Mohammed Salah Ahmed Teiama

Dr. Mohammed Salah Ahmed Teiama is a dedicated Lecturer specializing in Pharmaceutics and Industrial Pharmacy at Galala University’s Faculty of Pharmacy. Born in June 1984 and married with two daughters, he holds a significant academic journey. Dr. Teiama received his bachelor’s, master’s, and PhD degrees from the Faculty of Pharmacy at Helwan University. His master’s research focused on “Formulation and Evaluation of Pharmaceutical Preparations Containing a Model Anticancer Drug,” while his PhD work delved into “Formulation and Evaluation of Targeted Drug Delivery Systems for Treatment of Cancer Stem Cells.” Notably, he spent two years as a fully funded scholar from the Egyptian Ministry of Higher Education, engaged in practical work at the Cellular Engineering and Nano-Therapeutics Laboratory, Biomedical Engineering Department, University of Michigan. Here, he contributed to a project involving siRNA delivery to head and neck cancer stem cells, under the guidance of Professor Mohamed Elsayed. Dr. Teiama achieved a significant milestone by successfully passing the Associate Professor committee in October 2022. His expertise lies in formulating nanoparticles and their comprehensive characterization through experimental approaches. This entails utilizing various polymers and advanced techniques to create nanoparticles, followed by meticulous result analysis. Presently, he collaborates with fellow department members on diverse projects to contribute to the advancement of pharmaceutical sciences.

• Gemcitabine analogue loaded lipid formulae for treatment of different types of cancer.

• • Gemcitabine is first line treatment for different tumors such as Breast cancer, lung cancer and Pancreatic cancer. Different analogues were recently reported as a promising treatment for different types of solid tumors. Therefore, in this work we synthesized Gemcitabine new analogue and made loading with a new nanoscale lipid formula. The formula is subjected for physical characterization and cell culture testing work.

• Appraisal on the wound healing potential of natural herbal extract nanoemulsion topical Preparations.

• • Two different oils were extracted from natural herb and recently reported as a promising treatment for skin infection and improving skin repair. Therefore, in this work we a nanoemulsion formula. The results indicated that the loaded oils became more potent in the NE formula and proved its efficacy in wound healing process.
  • Formulation of a Novel Nanoemulsion Formula Encapsulated with Thalidomide Analogue.
  • Thalidomide (THD) and its analogues were recently reported as a promising treatment for different types of solid tumors due to their antiangiogenic effect. Therefore, in this work we synthesized THD new analogue and made loading with a new nanoscale formula. The results indicated that THD analogue became more potent in the NE formula and proved its efficacy as a promising chemotherapy for cancer cell line.

• In vitro cytotoxicity and cellular uptake of Tamoxifen citrate-loaded polymeric micelles.

• • Cancer represents the second cause of death worldwide after ischemic heart diseases. Tamoxifen is one of the most available cheap and effective treatment for breast cancer. Preparation of a delivery system to improve cellular uptake and cytotoxicity of tamoxifen is a great challenge. Different polymeric micelles mixtures are promising target for our delivery system.   

• Formulation and optimization of advanced drug delivery system for BCS class II.

• • The limited bioavailability of BCS class II drug is mainly due to poor solubility. A delivery system will be fabricated by different polymers then optimized by exploring the effect of various formulation parameters. The candidate drug is used for treatment of Gout. The formulation will be evaluated comparatively for the; Entrapment efficiency, Particle size, Morphology, DSC, In-vitro drug release, In-vivo study. 

• Formulation and characterization of nanocarrier system for a CNS acting drug. 

• • Avoiding the first pass hepatic metabolism of the drug through a suitable route of administration to minimize the dose and side effects of the drug. The delivery system will be prepared by one or more of the selected methods and optimization of formulations by exploring the effect of various formulation parameters. The formulation will be evaluated comparatively for the; Entrapment efficiency, Particle size, Morphology, DSC, In-vitro drug release, In-vivo study.

•  Design and Synthesis of Targeted, Degradable, Membrane-Destabilizing, pH-Sensitive β-Cyclodextrin Particles for the Cytoplasmic Delivery of Anti-Bmi-1 siRNA to Suppress Head and Neck Squamous Cell Carcinoma In-Vitro and In-Vivo:

• • Synthesis of a library of targeted, degradable, star-shaped β-CD polymers that can efficiently and functionally deliver the desired dose of anti- Bmi-1 siRNA at low N/P ratios (2.5/1) into the cytoplasm of cisplatin resistant head and neck squamous cell carcinoma by utilizing the varying reactivity of primary and secondary hydroxyl groups of the β-CD core. Briefly, the secondary face was modified to couple hydrophobic hexamethyl acrylate (HMA) and pH-sensitive N, N-Dimethylaminoethyl Methacrylate (DMAEMA) (1:1 mol ratio, 25kDa, 5.5 grafts/ β-CD) copolymer grafts via an acid labile linkage to ensure dual endosomal escape. 50% of DMAEMA monomer was converted to cationic TMAEMA to ensure electrostatic coupling of anti-Bmi-1 siRNA.

• Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions:

• • Formulation of secondary and ternary solid dispersion to improve the absorption of poorly water-soluble drug. The solid dispersion exhibit better rate and extent of solubility and absorption which improve drug bioavailability. This technique was successfully used with Tamoxifen citrate, that is a medicine used for treatment of breast cancer. Animal studies exhibited high plasma level and lower hepatic accumulation than market products.

• In-Situ Injectable Thermosensitive Gel Based On Poloxamer as A New Carrier For Tamoxifen Citrate.

• Formulation of In-situ thermosensitive gel to reduce the toxicity of poorly water-soluble drug and localize anticancer activities of Tamoxifen citrate which is widely used for treatment of breast cancer. The main idea was to prepare liquid solution of Tamoxifen citrate under ow temperature (4 0C) which easily injected into human body to be transformed into gel form due to the elevated temperature if human body (37 0C). Animal studies exhibited higher accumulation in breast tissue and lower appearance in plasma and liver in comparison with oral administration.

• Postdoc scholar at Wayne state University (6 months, November 2021 to April 2022), funded by Mission Department, Ministry of Higher Education, Cairo, Egypt
• PhD degree with Excellence May 2017
• Best Master Thesis, Basic Sciences Field, University of Helwan, 2013-2014.
• Joint Supervision, at Biomedical Engineering Department, University of Michigan, funded by Mission Department, High Education Ministry, Egypt, 2014-2017.
• Master’s degree with Excellence August 2012
• The Ideal Pharmacist in Faculty of Pharmacy, Helwan University, Egyptian Syndicate Ceremony, 2008.
• Graduated with Excellent “with honors”, 7th of Alumni 2006

• Lecturer of Pharmaceutics and Industrial Pharmacy, Pharmaceutics Department, Faculty of Pharmacy, Galala University, October 2022.
• Lecturer of Biopharmaceutics and Pharmacokinetics, Cosmetics, Advanced Drug Delivery, Sterile products, and Dosage form II: October University for Modern Science and ART (MSA) Spring semester 2017/2019. 
• Lecturer of Biopharmaceutics and Pharmacokinetics, Drug Design, and Industrial Pharmacy: Al-Ahram Canadian University (ACU) Spring semester 2017/2019. 
• Lecturer of Pharmaceutics and Industrial Pharmacy from July 2017 up to Now: Lecturer of Physical Pharmacy, Quality Control, Industrial Pharmacy, Pharmaceutical Legalizations, Pharmaceutical Cosmetology, Pharmacy administration for undergraduate student – and Lecturer of Computer Sciences, Pharmaceutical Dosage Form II, Radiopharmaceuticals, Drug stability and Drug kinetics, Advanced Drug Delivery, Physical Pharmacy postgraduate students (master &PhD degree). 
• PhD student, Visiting Scholar, Joint Supervision from July 2014 to May 2017: Cellular Engineering and Nanotechnology laboratory, Biomedical Engineering Department, Engineering School, University of Michigan – Working for the practical part of the PhD Thesis. Supervision: Ass. Prof. Dr. Mohamed Elsayed.
• Assistant Lecturer of Pharmaceutics and Industrial Pharmacy from October 2012 to May 2017: Teaching and supervision for practical laboratory of Physical Pharmacy, Pharmaceutics I, Pharmaceutics II, Pharmaceutics III, Quality Control, Industrial Pharmacy, Pharmaceutical Cosmetology, Pharmacokinetics and Biopharmaceutics, Drug Stability and Drug Kinetics for undergraduate students.
• Demonstrator of Pharmaceutics and Industrial Pharmacy from February 2007 to October 2012: Teaching and supervision for practical laboratory of Physical Pharmacy, Pharmaceutics 1, Pharmaceutics 2, Pharmaceutics 3, Quality Control, Industrial Pharmacy, Pharmaceutical Cosmetology, Pharmacokinetics and Biopharmaceutics, Drug Stability and Drug Kinetics for undergraduate students.
• Participate in the development of the practical part of the physical pharmacy course, pharmacy technology, industrial pharmacy, and pharmacy management, assigning students to conduct scientific research and educational activities related to courses such as pharmacy management, pharmaceutical legislation, pharmacy technology, pharmaceutical control, and quality assurance.
• Activating student scientific research and activities and forming discussion committees to discuss research with students for more than one course in the department.
• Supervising summer training for groups of bachelor’s students within the graduation requirements of the Bachelor of Pharmacy program from 2017 until now.
• Participation in setting theoretical, practical and oral exams for all teams of the Bachelor of Pharmaceutical Sciences program, clinical pharmacy programs, PharmD, PharmD Clinical, Pre-Masters, Pre-PhD and all exams related to them from the academic year 2017/2018 until now in the Department of Pharmaceutics.
• A member of the control team for clinical pharmacy program exams from 2017 to 2021.
• Member of the control of the fourth-year exams for the academic year 2017/2018.
• A member of the cumulative examinations control for the bachelor’s program in the college since its formation in 2018 until now.

• Member of Organization Committee of First, Second, Third, Fourth and Fifth International Conference, Faculty of Pharmacy, Helwan University: 1-2 October 2017, 15-16 September 2018, September 2019, and November 2020.
• Supervisor for Student Union and Coordinator for Student Union Activities, Faculty of Pharmacy, Helwan University: From September 2017.
• Member of Hub for Creativity and Scientific Research, Helwan University, From November 2019 to now.
• Member of the Infrastructure and Laboratory Equipment Development Project, Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, (2019 – 2021), funded by Strategic planning sector, Helwan University.
• Member of the Helwan University Central laboratory Project, Helwan University, (2019 – 2021), funded by Strategic planning sector, Helwan University.
• Head of Undergraduate Training Committee, Faculty of Pharmacy, Helwan University, from August 2021.

• Coordinator of student activities and the Student Union in the college from 2017 until now.
• Participate in supervising student activities in the department and supervising summer training for college students
• Coordinator of the College in the Entrepreneurship Club, which aims to develop students’ abilities
• Participation in organizing the college graduates’ ceremony for the year 2020/2021 at the Center for Arts and Culture, Helwan University.
• Participation in the preparation of the Stack holder alumni symposium
• Participation in the membership of the 2021/2022 Graduate Ceremony Organizing Committee
• A member of some committees of the Faculty of Pharmacy – Helwan University, namely: Laboratories Committee from September 2017 – Community Service and Environmental Development Committee from September 2017 – Education and Student Affairs Committee

Mohammed.Teiama@gu.edu.eg