Dr. Mohamed Teiama’s career in Pharmaceutics and Industrial Pharmacy is characterized by a deep commitment to research and innovation. As an associate professor at the Faculty of Pharmacy, Galala University, Egypt, he has made significant contributions to the field through his academic achievements and practical experiences.
Dr. Teiama obtained his bachelor’s, master’s, and PhD degrees from the Faculty of Pharmacy at Helwan University, focusing his studies on pharmaceutical formulations and drug delivery systems. His master’s thesis, titled “Formulation and Evaluation of Pharmaceutical Preparations Containing a Model Anticancer Drug,” and his PhD dissertation, titled “Formulation and Evaluation of Targeted Drug Delivery Systems for Treatment of Cancer Stem Cells,” demonstrate his specialization in developing advanced drug delivery technologies, particularly for cancer therapy.
In pursuit of practical experience and further expertise, Dr. Teiama spent two years conducting research at the Biomedical Engineering Department, University of Michigan, as a fully funded scholar from the Egyptian Ministry of Higher Education. During this time, he worked on a project focusing on the delivery of siRNA to head and neck cancer stem cells, under the supervision of Professor Mohamed Elsayed at the Cellular Engineering and Nano-Therapeutics Laboratory. This experience provided him with invaluable insights and skills in the development and characterization of nanoparticle-based drug delivery systems.
Dr. Teiama’s dedication to research excellence continued as he pursued a funded postdoctoral fellowship at the College of Pharmacy and Health Sciences, Wayne State University, Michigan, USA, from 2021 to 2022. Throughout his career, he has demonstrated expertise in formulating nanoparticles and characterizing them at various levels, utilizing advanced techniques and methodologies to advance drug delivery science.
Currently, Dr. Teiama is actively involved in collaborative research projects with his colleagues in the department, furthering his contributions to the field of Pharmaceutics and Industrial Pharmacy. His expertise, coupled with his passion for innovation, positions him as a leading figure in the development of novel drug delivery systems and nanoparticle formulations, with the potential to impact the treatment of various diseases, including cancer.
Nanocarriers as a promising delivery system
Gene delivery for cancer treatment
Formulation and evaluation of drug delivery system of herbal and natural products
Gemcitabine analogue loaded lipid formulae for treatment of different types of cancer.
Gemcitabine is first line treatment for different tumors such as Breast cancer, lung cancer and Pancreatic cancer. Different analogues were recently reported as a promising treatment for different types of solid tumors. Therefore, in this work we synthesized Gemcitabine new analogue and made loading with a new nanoscale lipid formula. The formula is subjected for physical characterization and cell culture testing work.
Appraisal on the wound healing potential of natural herbal extract nanoemulsion topical Preparations.
Two different oils were extracted from natural herb and recently reported as a promising treatment for skin infection and improving skin repair. Therefore, in this work we a nanoemulsion formula. The results indicated that the loaded oils became more potent in the NE formula and proved its efficacy in wound healing process.
Formulation of a Novel Nanoemulsion Formula Encapsulated with Thalidomide Analogue.
Thalidomide (THD) and its analogues were recently reported as a promising treatment for different types of solid tumors due to their antiangiogenic effect. Therefore, in this work we synthesized THD new analogue and made loading with a new nanoscale formula. The results indicated that THD analogue became more potent in the NE formula and proved its efficacy as a promising chemotherapy for cancer cell line.
In vitro cytotoxicity and cellular uptake of Tamoxifen citrate-loaded polymeric micelles.
Cancer represents the second cause of death worldwide after ischemic heart diseases. Tamoxifen is one of the most available cheap and effective treatment for breast cancer. Preparation of a delivery system to improve cellular uptake and cytotoxicity of tamoxifen is a great challenge. Different polymeric micelles mixtures are promising target for our delivery system.
Formulation and optimization of advanced drug delivery system for BCS class II.
The limited bioavailability of BCS class II drug is mainly due to poor solubility. A delivery system will be fabricated by different polymers then optimized by exploring the effect of various formulation parameters. The candidate drug is used for treatment of Gout. The formulation will be evaluated comparatively for the; Entrapment efficiency, Particle size, Morphology, DSC, In-vitro drug release, In-vivo study.
Formulation and characterization of nanocarrier system for a CNS acting drug.
Avoiding the first pass hepatic metabolism of the drug through a suitable route of administration to minimize the dose and side effects of the drug. The delivery system will be prepared by one or more of the selected methods and optimization of formulations by exploring the effect of various formulation parameters. The formulation will be evaluated comparatively for the; Entrapment efficiency, Particle size, Morphology, DSC, In-vitro drug release, In-vivo study.Design and Synthesis of Targeted, Degradable, Membrane-Destabilizing, pH-Sensitive β-Cyclodextrin Particles for the Cytoplasmic Delivery of Anti-Bmi-1 siRNA to Suppress Head and Neck Squamous Cell Carcinoma In-Vitro and In-Vivo.
Synthesis of a library of targeted, degradable, star-shaped β-CD polymers that can efficiently and functionally deliver the desired dose of anti- Bmi-1 siRNA at low N/P ratios (2.5/1) into the cytoplasm of cisplatin resistant head and neck squamous cell carcinoma by utilizing the varying reactivity of primary and secondary hydroxyl groups of the β-CD core. Briefly, the secondary face was modified to couple hydrophobic hexamethyl acrylate (HMA) and pH-sensitive N, N-Dimethylaminoethyl Methacrylate (DMAEMA) (1:1 mol ratio, 25kDa, 5.5 grafts/ β-CD) copolymer grafts via an acid labile linkage to ensure dual endosomal escape. 50% of DMAEMA monomer was converted to cationic TMAEMA to ensure electrostatic coupling of anti-Bmi-1 siRNA.
Comparative Studies on Dissolution and Bioavailability of Tamoxifen Citrate Loaded Binary and Ternary Solid Dispersions.
Formulation of secondary and ternary solid dispersion to improve the absorption of poorly water-soluble drug. The solid dispersion exhibit better rate and extent of solubility and absorption which improve drug bioavailability. This technique was successfully used with Tamoxifen citrate, that is a medicine used for treatment of breast cancer. Animal studies exhibited high plasma level and lower hepatic accumulation than market products.
In-Situ Injectable Thermosensitive Gel Based On Poloxamer as A New Carrier For Tamoxifen Citrate.
Formulation of In-situ thermosensitive gel to reduce the toxicity of poorly water-soluble drug and localize anticancer activities of Tamoxifen citrate which is widely used for treatment of breast cancer. The main idea was to prepare liquid solution of Tamoxifen citrate under ow temperature (4 0C) which easily injected into human body to be transformed into gel form due to the elevated temperature if human body (37 0C). Animal studies exhibited higher accumulation in breast tissue and lower appearance in plasma and liver in comparison with oral administration.